To make the most facile counterpoint - the reason the Skyrim blacksmith doesn't care if the main character slays dragons is because they weren't programmed to. There aren't consequences either way.
To the extent that this post is meant to be inspiring, it only works if you're an NPC in a static world that has no real consequences - where you actually can live your life in a static loop because nothing will change.
When the metaphorical dragon comes to burn down your village, are you going to shrug and go back to looping your hammer_nail_03 animation?
I think when people use NPC as an insult (it is a dumb insult in my opinion), they are looking at it from the point of view of a player, someone outside the game who understands that the NPC is scripted (this is a silly and egotistical way of looking at the world). This post is looking from it from the point of view of the NPC instead, as if that was a living entity one could be.
In Hades, yes. Vanishingly few of us actually control our fates or societies even to a small extent. The modern tendency to think like we do is a form of mania. By indulging it, we damage the only control we really have, our relative health and peace of mind.
New Quest Added: slay dragon
The example is particularly bad because in Skyrim the blacksmith actually does react when a dragon arrives (in one of the villages where the blacksmith is on an exterior cell) and can actually be hurt by the dragon.