Entire classes of allergies are basically caused by IgE, our worm-targeting depth charges, getting bored by the lack of worms in our bodies for possibly the first time in millennia.
If we could tweak our bodies we wouldn’t want to eliminate IgE. But we’d want to have it produced only when a recognizer complex finds thar be worms.
How can IgE get bored? That doesn’t sound right. Why would the body, a master of efficiency, produce IgE just for fun?
More likely that there are enough toxins unknowingly mixed into our food which trigger the responses. There is a severe lack of analytical methods and constant monitoring of the food we eat (e.g. food plus packaging plus time and temperature).